High Titer of Autoantibodies to GAD Identifies a Specific Phenotype of Adult-Onset Autoimmune Diabetes
Response to Buzzetti et al.
- Tetsuro Kobayashi, MD, PHD1,
- Shoichiro Tanaka, MD, PHD1,
- Akira Shimada, MD, PHD2 and
- Taro Maruyama, MD, PHD3
- 1Third Department of Internal Medicine, University of Yamanashi, Yamanashi, Japan
- 2Department of Internal Medicine, Keio University, Tokyo, Japan
- 3Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, Japan
- Address correspondence to Tetsuro Kobayashi, the Third Department of Internal Medicine, University of Yamanashi, Chuo-City, 409-3898, Yamanashi, Japan. E-mail: tetsurou{at}yamanashi.ac.jp
Buzzetti et al. (1) reported a presence of two subgroups of adult-onset autoimmune diabetes at the cutoff value of GAD antibodies (GADA) titer of 32 arbitrary units (AU). Our previous report on a prospective-based observation of a Japanese population demonstrated that high GADA titer (>10 AU) is critical for predicting the progression within 5 years …
