Diabetes, Depression, and Death

A randomized controlled trial of a depression treatment program for older adults based in primary care (PROSPECT)

  1. Hillary R. Bogner, MD, MSCE1,
  2. Knashawn H. Morales, SCD2,
  3. Edward P. Post, MD, PHD34 and
  4. Martha L. Bruce, PHD, MPH5
  1. 1Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, Pennsylvania
  2. 2Center for Clinical Epidemiology and Biostatistics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
  3. 3Veterans Affairs Health Services Research and Development and National Serious Mental Illness Treatment Research and Evaluation Center, Ann Arbor, Michigan
  4. 4Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
  5. 5Department of Psychiatry, Weill Medical College of Cornell University, White Plains, New York
  1. Address correspondence and reprint requests to Hillary R. Bogner, MD, Department of Family Practice and Community Medicine, University of Pennsylvania, 3400 Spruce St., 2 Gates Building, Philadelphia, PA 19104. E-mail: hillary.bogner{at}uphs.upenn.edu


OBJECTIVE—We sought to test our a priori hypothesis that depressed patients with diabetes in practices implementing a depression management program would have a decreased risk of mortality compared with depressed patients with diabetes in usual-care practices.

RESEARCH DESIGN AND METHODS—We used data from the multisite, practice-randomized, controlled Prevention of Suicide in Primary Care Elderly: Collaborative Trial (PROSPECT), with patient recruitment from May 1999 to August 2001, supplemented with a search of the National Death Index. Twenty primary care practices participated from the greater metropolitan areas of New York City, New York; Philadelphia, Pennsylvania; and Pittsburgh, Pennsylvania. In all, 584 participants identified though a two-stage, age-stratified (aged 60–74 or ≥75 years) depression screening of randomly sampled patients and classified as depressed with complete information on diabetes status are included in these analyses. Of the 584 participants, 123 (21.2%) reported a history of diabetes. A depression care manager worked with primary care physicians to provide algorithm-based care. Vital status was assessed at 5 years.

RESULTS—After a median follow-up of 52.0 months, 110 depressed patients had died. Depressed patients with diabetes in the intervention category were less likely to have died during the 5-year follow-up interval than depressed diabetic patients in usual care after accounting for baseline differences among patients (adjusted hazard ratio 0.49 [95% CI 0.24–0.98]).

CONCLUSIONS—Older depressed primary care patients with diabetes in practices implementing depression care management were less likely to die over the course of a 5-year interval than depressed patients with diabetes in usual-care practices.


  • Published ahead of print at http://care.diabetesjournals.org on 23 August 2007. DOI: 10.2337/dc07-0974. Clinical trial reg. no. NCT00000367, clinicaltrials.gov.

    A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted August 18, 2007.
    • Received May 21, 2007.
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  1. Diabetes Care vol. 30 no. 12 3005-3010
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