Lifestyle Intervention and Adipokine Levels in Subjects at High Risk for Type 2 Diabetes

The Study on Lifestyle intervention and Impaired glucose tolerance Maastricht (SLIM)

  1. Eva Corpeleijn, PHD1,
  2. Edith J.M. Feskens, PHD23,
  3. Eugène H.J.M. Jansen, PHD4,
  4. Marco Mensink, MD, PHD1,
  5. Wim H.M. Saris, MD, PHD1 and
  6. Ellen E. Blaak, PHD1
  1. 1Human Biology, Nutrition and Toxicology Research Institute, Maastricht, the Netherlands
  2. 2Human Nutrition, Wageningen University and Research Center, Wageningen, the Netherlands
  3. 3Centre for Nutrition and Health, National Institute for Public Health and Environment, Bilthoven, the Netherlands
  4. 4Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and Environment, Bilthoven, the Netherlands
  1. Address correspondence and reprint requests to Eva Corpeleijn, PHD, Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, Netherlands. E-mail: e.corpeleijn{at}hb.unimaas.nl

Abstract

OBJECTIVE—We investigated whether circulating adipokine concentrations can be altered by lifestyle intervention according to general recommendations in subjects at risk for diabetes as well as the potential of leptin, adiponectin, and resistin as biomarkers for lifestyle-induced improvements in glucose metabolism and insulin resistance.

RESEARCH DESIGN AND METHODS—In the Study on Lifestyle intervention and Impaired glucose tolerance Maastricht, 147 men and women with impaired glucose tolerance (IGT) were randomized to either a combined diet-and-exercise intervention or a control program. At baseline and after 1 year, an oral glucose tolerance test, an exercise test, and anthropometric measurements were performed. After 1 year, complete data of 103 subjects (50 intervention and 53 control subjects) were obtained.

RESULTS—Lifestyle intervention reduced plasma leptin concentrations (−14.2%) in IGT subjects but did not alter plasma adiponectin (−0.3%) or resistin (−6.5%) concentrations despite marked improvements in glucose tolerance and insulin resistance.

CONCLUSIONS—Changes in leptin concentration were related to improvements in insulin sensitivity independent of changes in body composition.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 21 September 2007. DOI: 10.2337/dc07-0457.

    A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    • Accepted September 14, 2007.
    • Received March 7, 2007.
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  1. Published online before print September 21, 2007, doi: 10.2337/dc07-0457 Diabetes Care December 2007 vol. 30 no. 12 3125-3127
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