Impaired Postprandial Blood Flow in Adipose Tissue May Be an Early Marker of Insulin Resistance in Type 2 Diabetes

  1. George Dimitriadis, MD, DPHIL1,
  2. Vaia Lambadiari, MD1,
  3. Panayota Mitrou, MD1,
  4. Eirini Maratou, PHD2,
  5. Eleni Boutati, MD1,
  6. Demosthenes B. Panagiotakos, PHD3,
  7. Theofanis Economopoulos, MD1 and
  8. Sotirios A. Raptis, MD12
  1. 12nd Department of Internal Medicine—Propaedeutic and Research Institute, Athens University Medical School, “Attikon” University Hospital Athens, Greece
  2. 2Hellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and Its Complications (HNDC), Athens, Greece
  3. 3Nutrition Science-Dietetics, Harokopio University, Athens, Greece
  1. Address correspondence and reprint requests to George Dimitriadis, MD, Internal Medicine, Athens University, “Attikon” University Hospital, 1 Rimini St., GR-12462 Haidari, Greece. E-mail: gdimi{at}ath.forthnet.gr and gdimitr{at}med.uoa.gr

Abstract

OBJECTIVE—We investigated the changes in subcutaneous adipose tissue blood flow (ATBF) after a meal in the various stages of type 2 diabetes.

RESEARCH DESIGN AND METHODS—Five groups were examined: healthy control subjects, first-degree relatives of subjects with type 2 diabetes, subjects with impaired glucose tolerance (IGT), subjects with type 2 diabetes and postprandial hyperglycemia but normal fasting plasma glucose levels (diabetes group A [DMA]), and subjects with type 2 diabetes with both postprandial and fasting hyperglycemia (diabetes group B [DMB]). ATBF was measured with 133Xe.

RESULTS—ATBF was higher in control subjects (1,507 ± 103 ml/100 cm3 tissue × min) versus relatives and IGT, DMA, and DMB subjects (845 ± 123, 679 ± 69, 765 ± 60, and 757 ± 69 ml/100 cm3 tissue × min, respectively; P < 0.001). Insulin sensitivity index (ISI) in control subjects (82 ± 3 mg × l2/mmol × mU × min) was higher versus that for relatives and IGT, DMA, and DMB subjects (60 ± 3, 45 ± 1, 40 ± 6, and 29 ± 4 mg × l2/mmol × mU × min, respectively; P < 0.0001). ISI was positively associated with peak-baseline ATBF (β coefficient 0.029 ± 0.013, P = 0.03).

CONCLUSIONS—After meal ingestion, insulin-stimulated ATBF was decreased in relatives and and IGT, DMA, and DMB subjects. This defect could be an early marker of insulin resistance that precedes the development of type 2 diabetes.

Footnotes

  • G.D. and V.L. contributed equally to the work presented in this article.

    Published ahead of print at http://care.diabetesjournals.org on 21 September 2007. DOI: 10.2337/dc07-0699.

    A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    • Accepted September 14, 2007.
    • Received April 10, 2007.
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  1. Published online before print September 21, 2007, doi: 10.2337/dc07-0699 Diabetes Care December 2007 vol. 30 no. 12 3128-3130
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