Islet Autotransplantation Restores Normal Glucose Tolerance in a Patient With Chronic Pancreatitis

  1. Severine Illouz, PHD1,
  2. M'Balu Webb, MSC1,
  3. Cristina Pollard, BA1,
  4. Patrick Musto, FCA(SA)2,
  5. Kieran O'Reilly, MBCHB3,
  6. David Berry, MD1 and
  7. Ashley Dennison, MD1
  1. 1Department of Hepatobiliary and Pancreatic Surgery, University Hospital of Leicester, Leicester, U.K
  2. 2Department of Anesthesiology, University Hospital of Leicester, Leicester, U.K
  3. 3Department of Pathology, University Hospital of Leicester, Leicester, U.K
  1. Address correspondence to Dr. Severine Illouz, PhD, Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, U.K. E-mail: severine.illouz{at}uhl-tr.nhs.uk

Impaired glucose tolerance is a frequent complication of chronic pancreatitis (CP) that over time leads to diabetes (1). Intractable abdominal pain from CP that can no longer be managed by oral pancreatic enzymes and by narcotic analgesics is treated by surgery. To avoid diabetes onset following pancreatectomy, combined islet autotransplantation has been offered to the patients who suffered from CP in Leicester, U.K., since 1994 (2,3) (http://hpb.org.uk/hpbunitspecialist.php?page_id=11).

Here, we present a case report of a patient that suffered from CP and had an abnormal oral glucose tolerance test (OGTT) …

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