Possible Relevance of HLA-DRB1*0403 Haplotype in Insulin Autoimmune Syndrome Induced by α-Lipoic Acid, Used as a Dietary Supplement
- Tetsuya Yamada, MD, PHD,
- Junta Imai, MD, PHD,
- Yasushi Ishigaki, MD, PHD,
- Yoshinori Hinokio, MD, PHD,
- Yoshitomo Oka, MD, PHD and
- Hideki Katagiri, MD, PHD
- From the Department of Diabetes and Metabolism, Tohoku University Hospital, Sendai, Japan
- Address correspondence to Dr. Hideki Katagiri, Department of Diabetes and Metabolism, Tohoku University Hospital, Seiryo, Aoba, Sendai, 980-8575, Japan. E-mail: katagiri{at}mail.tains.tohoku.ac.jp
Insulin autoimmune syndrome (IAS) is characterized by frequent hypoglycemic attacks associated with the presence of autoantibodies to insulin in patients who have not received insulin injections. Approximately half of IAS patients have a medication history before onset, and over 90% of the agents are sulfydryl compounds such as methimazole, mercaptopropionyl glycine, or glutathione. In addition to these compounds, α-lipoic acid (ALA), which is widely used as a health supplement, …
