Serum Adiponectin and Renal Dysfunction in Men With Type 2 Diabetes

  1. Julie Lin, MD, MPH12,
  2. Frank B. Hu, MD, PHD134 and
  3. Gary Curhan, MD, SCD124
  1. 1Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
  2. 2Renal Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
  3. 3Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
  4. 4Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
  1. Address correspondence and reprint requests to Julie Lin, MD, MPH, Renal Division, Brigham and Women’s Hospital, 75 Francis St., Boston, MA 02115. E-mail: jlin11{at}partners.org

Abstract

OBJECTIVE—Inflammation is associated with both chronic kidney dysfunction and type 2 diabetes. Adiponectin, a novel circulating anti-inflammatory protein made by adipocytes, has been reported to be lower in diabetic than nondiabetic subjects. In contrast, serum levels of adiponectin are elevated in end-stage renal disease. We sought to investigate the relation between adiponectin and mild to moderate renal dysfunction in men with type 2 diabetes.

RESEARCH DESIGN AND METHODS—Multivariate logistic regression was used to evaluate the relation between serum adiponectin concentrations and the presence of renal dysfunction (estimated glomerular filtration rate [eGFR] <60 ml/min per 1.73 m2 by the four-variable Modification of Diet in Renal Disease equation) in participants with type 2 diabetes in the Health Professionals’ Follow-Up Study. A total of 733 men were included in this cross-sectional analysis.

RESULTS—Adiponectin was positively correlated with age (Spearman coefficient, r = 0.19, P < 0.001) and negatively correlated with weight (Spearman coefficient, r = −0.18, P < 0.001). Those with adiponectin in the second quartile or higher (>10 μg/ml) compared with those in the first quartile had a reduced odds for renal dysfunction (multivariate odds ratio 0.48 [95% CI 0.28–0.81]). These results were unchanged when serum lipids were included in the multivariate model.

CONCLUSIONS—We conclude that a higher serum adiponectin concentration is associated with reduced odds of moderate renal dysfunction in men with type 2 diabetes.

Footnotes

  • A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted November 4, 2006.
    • Received June 21, 2006.
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  1. doi: 10.2337/dc06-1296 Diabetes Care February 2007 vol. 30 no. 2 239-244
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