Tai Chi Chuan Exercise Decreases A1C Levels Along With Increase of Regulatory T-Cells and Decrease of Cytotoxic T-Cell Population in Type 2 Diabetic Patients
- Shu-Hui Yeh, PHD12,
- Hau Chuang, MS34,
- Li-Wei Lin, MS5,
- Chiu-Yueh Hsiao, MS6,
- Pei-Wen Wang, MD47 and
- Kuender D. Yang, MD, PHD34
- 1Department of Nursing, Chang Gung Institute of Technology, Kwei-Shan, Taoyuan, Taiwan
- 2Department of Nursing, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan
- 3Department of Medical Research, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kwei-Shan, Taoyuan, Taiwan
- 4Chang Gung University, Kwei-Shan, Taoyuan, Taiwan
- 5Department of Nursing, Fooyin University, Kaohsiung, Taiwan
- 6Department of Nursing, Tzu-Hui Institute of Technology, Ping-Tung, Taiwan
- 7Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan
- Address correspondence and reprint requests to Kuender D. Yang, MD, PhD, Medical Research, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung 833, Taiwan. E-mail: yangkd{at}adm.cgmh.org.tw
Type 2 diabetes is a metabolic syndrome associated with chronic inflammation (1–3). Although exercise training has been proven beneficial in treatment of type 2 diabetes (4,5), this preventive and therapeutic modality remains underused (5). Recently, evidence (6) indicates that physical inactivity can increase proinflammatory burden independently of obesity, and exercise may induce anti-inflammatory mediators (7). Strenuous exercise has been shown to augment proinflammatory reaction (8,9) and compromise adaptive immunity with a higher risk of upper respiratory tract infections (9,10). Moreover, strenuous exercise might also potentiate hypoglycemia in elderly diabetic patients (11). In contrast, certain studies show that moderate exercise enhances T-cell function (12) and decreases respiratory infections (13), which suggests that the volume of exercise is a critical element of inducing a positive or negative immune response in diabetic patients. Tai Chi Chuan (TCC) exercise, a traditional Chinese martial art that is classified as a moderate exercise because it does not demand >55% of maximal oxygen intake (14), can benefit balance and cardiovascular and respiratory function (14–16). We have previously shown (17) that a regular TCC exercise for 12 weeks significantly enhances functional mobility and regulatory T-cell function of normal adult volunteers; however, we could not assess the effect of TCC …
