Beneficial Effects of a 4-Week Exercise Program on Plasma Concentrations of Adhesion Molecules
- Anke Tönjes, MD1,
- Markus Scholz, PHD2,
- Mathias Fasshauer, MD1,
- Jürgen Kratzsch, PHD3,
- Fauci Rassoul, PHD3,
- Michael Stumvoll, MD1 and
- Matthias Blüher, MD1
- 1Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
- 2Institute for Medical Informatics, Statistics, and Epidemiology, University of Leipzig, Leipzig, Germany
- 3Institute of Clinical Chemistry and Pathobiochemistry, University of Leipzig, Leipzig, Germany
- Address correspondence to Prof. Dr. M. Blüher, Medical Department III, University of Leipzig, Ph.-Rosenthal-Str. 27, D-04103 Leipzig. E-mail: bluma{at}medizin.uni-leipzig.de
Plasma concentrations of adhesion molecules are elevated in patients with endothelial dysfunction and atherosclerosis (1), as well as in patients with impaired glucose tolerance (IGT) or type 2 diabetes—even those without angiographic evidence for atherosclerosis (2). Physical activity is associated with reduced risk of cardiovascular disease and total mortality in men with type 2 diabetes (3). The beneficial effects of physical activity could be mediated by improved markers of endothelial dysfunction, including adhesion molecules. We therefore tested the hypothesis that an intensive 4-week physical training program leads to improved plasma concentrations of intracellular …
