Flexible Intensive Insulin Therapy in Adults With Type 1 Diabetes and High Risk for Severe Hypoglycemia and Diabetic Ketoacidosis
Response to Pennant et al.
- Alexander Sämann, MD1,
- Ingrid Mühlhauser, MD2 and
- Ulrich A. Müller, MD1
- 1Department of Internal Medicine III, Friedrich-Schiller University, Jena, Germany
- 2Unit of Health Sciences and Education, University of Hamburg, Hamburg, Germany
- Address correspondence to Alexander Sämann, MD, Department of Internal Medicine III, Erlanger Allee 101, Friedrich-Schiller University, 07740 Jena, Germany. E-mail: alexander.saemann{at}med.uni-jena.de
As we previously discussed, regression to the mean was an important bias of our study, since it was not controlled (1,2). A subgroup analysis may or may not contribute to this bias. Pennant et al. (3) performed statistical simulations of baseline results and found that a reduction from 6.1 to 4.7 (95% CI ±0.2) hypoglycemic events per patient per year may be due to regression to the mean. However, there would still remain a reduction from 4.7 to 1.4 hypoglycemic events per patient per year, which was of clinical importance in this high-risk population.
The Diabetes Treatment and Teaching Program (DTTP) for type 1 diabetes has been extensively studied in …
