Plasma Retinol-Binding Protein-4 Concentrations Are Elevated in Human Subjects With Impaired Glucose Tolerance and Type 2 Diabetes
Response to Cho et al.
- Shai Gavi, DO, PHD1,
- Saima Qurashi, MD1,
- Mark M. Melendez, MD12,
- Dennis C. Mynarcik, PHD1,
- Margaret A. McNurlan, PHD2 and
- Marie C. Gelato, MD, PHD1
- 1Division of General Medicine and Geriatrics, Department of Medicine, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York
- 2Department of Surgery, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York
- Address correspondence to Shai Gavi, Division of General Medicine and Geriatrics, Department of Medicine, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794-8154. E-mail: sgavi{at}notes.cc.sunysb.edu
In their recent study, Cho et al. (1) demonstrated higher levels of retinol-binding protein-4 (RBP4) in in-dividuals with impaired glucose tolerance and type 2 diabetes. Additionally, higher waist circumferences increased with plasma RBP4 quartiles. This was also demonstrated by Graham et al. (2). Cho et al. suggested that visceral fat may be more important than total body fat in determining circulating RBP4 levels. In our study (3), we investigated whether visceral …
