Is There a Systemic Inflammatory Response in the Acute Charcot Foot?
- Nina L. Petrova, MD1,
- Caje Moniz, MD, FRCPATH2,
- David A. Elias, MD, FRCR3,
- Muriel Buxton-Thomas, MSC, FRCP4,
- Maureen Bates, MSC, DPODM1 and
- Michael E. Edmonds, MD, FRCP1
- 1Diabetic Foot Clinic, King's College Hospital, London, U.K.
- 2Department of Biochemistry, King's College Hospital, London, U.K.
- 3Department of Diagnostic Radiology, King's College Hospital, London, U.K.
- 4Department of Nuclear Medicine, King's College Hospital, London, U.K.
- Address correspondence and reprint requests to Dr. Nina Petrova, Diabetic Foot Clinic, King's College Hospital, Denmark Hill, London SE5 9RS. E-mail: petrovanl{at}yahoo.com
Although patients with acute Charcot osteoarthropathy exhibit a marked local inflammatory response to trauma by the classical presentation of a red, hot swollen foot, the systemic acute phase response has not been fully investigated. The aim of this study was to measure the systemic serologic markers of inflammation in acute Charcot osteoarthropathy.
RESEARCH DESIGN AND METHODS—
We studied 36 consecutive patients who presented to the Diabetic Foot Clinic over the last 5 years with a red, hot swollen foot and a skin temperature >2°C compared with the same site on the contralateral foot and who had no previous treatment. There was no evidence of any skin breakdown or ulceration. Foot skin temperatures were measured by Dermatemp 1001 (Exergen, Watertown, MA). The diagnosis of Charcot osteoarthropathy was confirmed in 25 cases by evidence of subluxation, dislocation, or fragmentation of bone on standard foot radiographs and in 11 cases by the presence of an increased focal uptake on the bony (third) phase of the triphasic Technetium-Diphosphonate bone scan (Tyco Healthcare) even though the radiographs at presentation were normal. In the patients with radiological abnormalities, the patterns of involvement were described using Sanders and Frykberg's classification (1). Four patients presented with pattern I …
