Evidence for Independent Heritability of the Glycation Gap (Glycosylation Gap) Fraction of HbA1c in Nondiabetic Twins
Response to Cohen et al.
- Frank Q. Nuttall, MD, PHD
- From the Minneapolis VA Medical Center, Minneapolis, Minnesota; and the Department of Medicine, University of Minnesota, Minneapolis, Minnesota
- Address correspondence to Frank Q. Nuttall, MD, PhD, Chief, Metabolic/Endocrine Section (111G), VA Medical Center, One Veterans Drive, Minneapolis, MN 55417. E-mail: nutta001{at}umn.edu
I have read with interest the article by Cohen et al. (1) in Diabetes Care. In this article, the authors reported a significant effect of heredity on the A1C values in twin subjects. This hereditary effect was attributed to “genes that preferentially affect erythrocyte lifespan or glucose and/or nonenzymatic glycation or deglycation in the intracellular rather …
