Advertisement

Adipokines and Risk of Type 2 Diabetes in Older Men

  1. S. Goya Wannamethee, PHD1,
  2. Gordon D.O. Lowe, FRCP2,
  3. Ann Rumley, PHD2,
  4. Lynne Cherry, PHD2,
  5. Peter H. Whincup, FRCP3 and
  6. Naveed Sattar, MD2
  1. 1Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, U.K.
  2. 2British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, U.K.
  3. 3Division of Community Health Sciences, St. George's Medical School, University of London, London, U.K.
  1. Address correspondence and reprint requests to Dr. S. Goya Wannamethee, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, U.K. E-mail: goya{at}pcps.ucl.ac.uk

Abstract

OBJECTIVE—The aim was to assess the relationship between adipokines, including interleukin (IL)-6, leptin, and adiponectin, with development of type 2 diabetes and assess the role of obesity and insulin resistance in these relationships.

RESEARCH DESIGN AND METHODS—We conducted a prospective study of 3,599 nondiabetic men aged 60–79 years and followed up for a mean period of 5 years, during which time there were 108 incident cases of type 2 diabetes.

RESULTS—Elevated IL-6, leptin, and low adiponectin were associated with increased risk of type 2 diabetes even after adjustment for BMI, lifestyle factors, preexisting cardiovascular disease, and systolic blood pressure. The relative risks (RRs) (top vs. bottom third) were 2.02 (95% CI 1.14–3.58) for IL-6, 1.91 (0.97–3.76) for leptin, and 0.40 (0.23–0.70) for adiponectin. Further adjustment for insulin resistance made minor differences to the IL-6 diabetes relationship (adjusted RR 2.12 [1.18–3.81]), weakened the associations with adiponectin (0.59 [0.33–1.04]), and abolished the association between leptin and diabetes (1.12 [0.55–2.26]). The inverse relation between low adiponectin and diabetes was significantly stronger in men who were obese (waist circumference >102 cm or BMI ≥30 kg/m2) (0.30 [0.11–0.79]) relative to leaner men (0.93 [0.44–1.96]) (test for interaction P = 0.04).

CONCLUSIONS—The association between leptin and incident diabetes is mediated by insulin resistance. By contrast, the positive association between IL-6 and diabetes appeared to be independent of obesity and insulin resistance. Finally, the association between low adiponectin and increased risk of diabetes appears to be significantly stronger in obese men than in leaner counterparts.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 23 February 2007. DOI: 10.2337/dc06-2416.

    A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted February 8, 2007.
    • Received November 27, 2006.
| Table of Contents

This Article

  1. Published online before print February 23, 2007, doi: 10.2337/dc06-2416 Diabetes Care May 2007 vol. 30 no. 5 1200-1205
  1. » Abstract
  2. Full Text
  3. Full Text (PDF)
  4. All Versions of this Article:
    1. dc06-2416v1
    2. 30/5/1200 most recent

Current Issue

  1. February 2012, 35 (2)
  1. Current Issue
  1. Alert me to new issues of Diabetes Care
Advertisement