Correspondence Between the International Diabetes Federation Criteria for Metabolic Syndrome and Insulin Resistance in a Cohort of Italian Nondiabetic Caucasians
The GISIR database
- Giorgio Sesti, MD1,
- Brunella Capaldo, MD2,
- Paolo Cavallo Perin, MD3,
- Stefano Del Prato, MD4,
- Lucia Frittitta, MD5,
- Simona Frontoni, MD6,
- Marta Letizia Hribal, PHD1,
- Giulio Marchesini, MD7,
- Giuseppe Paolisso, MD8,
- Pier Marco Piatti, MD9,
- Anna Solini, MD4,
- Enzo Bonora, MD10 and
- on behalf of the Group of Italian Scientists of Insulin Resistance (GISIR)*
- 1University of Catanzaro, Catanzaro, Italy
- 2University of Naples-Federico II, Naples, Italy
- 3University of Turin, Turin, Italy
- 4University of Pisa, Pisa, Italy
- 5University of Catania, Catania, Italy
- 6University of Rome-Tor Vergata, Rome, Italy
- 7University of Bologna, Bologna, Italy
- 8University of Naples II, Naples, Italy
- 9University of Milan-Vita e Salute, Milan, Italy
- 10University of Verona, Verona, Italy
- Address correspondence to Giorgio Sesti, MD, Medicina Sperimentale e Clinica, Policlinico, Universitario Mater Domini, Viale Europa, Campus Germaneto, 88100, Catanzaro, Italy. E-mail: sesti{at}unicz.it
In 2005, the International Diabetes Federation (IDF) released a consensus definition of the metabolic syndrome. The definition, intended to provide a feasible predictor of cardiovascular disease and type 2 diabetes, includes elevated waist circumference plus two of the following factors: reduced HDL cholesterol or raised blood pressure, triglycerides, or fasting glucose (1). Insulin resistance is a major pathogenic factor for the metabolic syndrome and may independently contribute to the risk of cardiovascular disease and type 2 diabetes (2). We assessed the diagnostic accuracy of the IDF definition of metabolic syndrome in identifying subjects with insulin resistance, defined as being in the lower quartile of insulin-stimulated glucose disposal (Mclamp) determined by a standardized hyperinsulinemic-euglycemic …
