New Insights on the Simultaneous Assessment of Insulin Sensitivity and β-Cell Function With the HOMA2 Method
Response to Nagasaka et al.
- Andrea Caumo1,
- Gianluca Perseghin, MD12,
- Amelia Brunani, MD3 and
- Livio Luzi, MD12
- 1Unit of Nutrition and Metabolism, Department of Medicine, San Raffaele Scientific Institute, Milan, Italy
- 2Faculty of Exercise Sciences, Physical Exercise for Health and Wellness Center, University of Milan, Milan, Italy
- 3Diabetes Research Unit, San Giuseppe Hospital, Instituto Auxologico Italiano, IRCCS, Verbania, Italy
- Address correspondence to Livio Luzi, MD, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy. E-mail: luzi.livio{at}hsr.it
We are very grateful to Nagasaka et al. (1) for their letter addressing relevant issues concerning the joint use of the homeostasis model assessment (HOMA)2 indexes (2,3). Nagasaka et al. measured the HOMA2 indexes of insulin sensitivity (HOMA-S%) and β-cell function (HOMA-B%) in 295 Japanese normal glucose tolerant men. They calculated the natural logarithm of the two indexes and used simple linear regression to analyze the relationship between the log-transformed indexes: ln(HOMA-B%) = a –b × ln(HOMA-S%). They found that the slope b was significantly lower than 1 and concluded that in their dataset the relationship between the HOMA2 indexes was not …
