Table of Contents

• Daniel J. Drucker

Dipeptidyl Peptidase-4 Inhibition and the Treatment of Type 2 Diabetes: Preclinical biology and mechanisms of action

• Bo Ahrén

Dipeptidyl Peptidase-4 Inhibitors: Clinical data and clinical implications

• Roland E. Schmieder,
• Christian Delles,
• Albert Mimran,
• Jean P. Fauvel,
• and Luis M. Ruilope

Impact of Telmisartan Versus Ramipril on Renal Endothelial Function in Patients With Hypertension and Type 2 Diabetes

• Klas Ekström,
• Jenny Salemyr,
• Ingmar Zachrisson,
• Christine Carlsson-Skwirut,
• Eva Örtqvist,
• and Peter Bang

Normalization of the IGF-IGFBP Axis by Sustained Nightly Insulinization in Type 1 Diabetes

• Hannele Yki-Järvinen,
• Leena Juurinen,
• Michael Alvarsson,
• Tord Bystedt,
• Ian Caldwell,
• Melanie Davies,
• Sanni Lahdenperä,
• Gil Nijpels,
• and Markku Vähätalo

Initiate Insulin by Aggressive Titration and Education (INITIATE): A randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups

• Daniel J. Cox,
• Linda Gonder-Frederick,
• Lee Ritterband,
• William Clarke,
• and Boris P. Kovatchev

Prediction of Severe Hypoglycemia

Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes: One-year results of the Look AHEAD trial

• Genevieve N. Healy,
• David W. Dunstan,
• Jo Salmon,
• Ester Cerin,
• Jonathan E. Shaw,
• Paul Z. Zimmet,
• and Neville Owen

Objectively Measured Light-Intensity Physical Activity Is Independently Associated With 2-h Plasma Glucose

• Sue J. Channon,
• Michelle V. Huws-Thomas,
• Stephen Rollnick,
• Kerenza Hood,
• Rebecca L. Cannings-John,
• Carol Rogers,
• and John W. Gregory

A Multicenter Randomized Controlled Trial of Motivational Interviewing in Teenagers With Diabetes

• Martha A. Hellems and
• William L. Clarke

Safe at School: A Virginia Experience

• Marcia A. Testa and
• Donald C. Simonson

Satisfaction and Quality of Life With Premeal Inhaled Versus Injected Insulin in Adolescents and Adults With Type 1 Diabetes

• Husam Ghanim,
• Priya Mohanty,
• Ram Pathak,
• Ajay Chaudhuri,
• Chang Ling Sia,
• and Paresh Dandona

Orange Juice or Fructose Intake Does Not Induce Oxidative and Inflammatory Response

• Sonia Vega-López,
• Lynne M. Ausman,
• John L. Griffith,
• and Alice H. Lichtenstein

Interindividual Variability and Intra-Individual Reproducibility of Glycemic Index Values for Commercial White Bread

• Brita Liljeström,
• Tiinamaija Tuomi,
• Bo Isomaa,
• Leena Sarelin,
• Katja Aktan-Collan,
• and Helena Kääriäinen

Adolescents at Risk for MODY3 Diabetes Prefer Genetic Testing Before Adulthood

• Subhashini Yaturu,
• Barbara Bryant,
• and Sushil K. Jain

Thiazolidinedione Treatment Decreases Bone Mineral Density in Type 2 Diabetic Men

• Hirofumi Makino,
• Masakazu Haneda,
• Tetsuya Babazono,
• Tatsumi Moriya,
• Sadayoshi Ito,
• Yasuhiko Iwamoto,
• Ryuzo Kawamori,
• Masahiro Takeuchi,
• and Shigehiro Katayama

Prevention of Transition From Incipient to Overt Nephropathy With Telmisartan in Patients With Type 2 Diabetes

• Lucrecia Herranz,
• Lourdes Saez-de-Ibarra,
• Cristina Grande,
• and Luis F. Pallardo

Non–Glycemic-Dependent Reduction of Late Pregnancy A1C Levels in Women With Type 1 Diabetes

Reduction of Microalbuminuria in Patients With Type 2 Diabetes: The Shiga Microalbuminuria Reduction Trial (SMART)

• Stefan Korsatko,
• Wolfgang Habacher,
• Ivo Rakovac,
• Johannes Plank,
• Sabine Seereiner,
• Peter Beck,
• Robert Gfrerer,
• Peter Mrak,
• Bernd Bauer,
• Manfred Großschädl,
• and Thomas R. Pieber

Evaluation of a Teaching and Treatment Program in Over 4,000 Type 2 Diabetic Patients After Introduction of Reimbursement Policy for Physicians

• Padmalatha Berikai,
• Peter M. Meyer,
• Rasa Kazlauskaite,
• Barbara Savoy,
• Kelly Kozik,
• and Leon Fogelfeld

Gain in Patients' Knowledge of Diabetes Management Targets Is Associated With Better Glycemic Control

• Vassili Valayannopoulos,
• Martine Vaxillaire,
• Yves Aigrain,
• Francis Jaubert,
• Christine Bellanné-Chantelot,
• Maria-Joao Ribeiro,
• Francis Brunelle,
• Philippe Froguel,
• Jean-Jacques Robert,
• Michel Polak,
• Claire Nihoul-Fékété,
• and Pascale de Lonlay

Coexistence in the Same Family of Both Focal and Diffuse Forms of Hyperinsulinism

• Gita D. Mishra,
• Gretchen Carrigan,
• Wendy J. Brown,
• Adrian G. Barnett,
• and Annette J. Dobson

Short-Term Weight Change and the Incidence of Diabetes in Midlife: Results from the Australian Longitudinal Study on Women's Health

• Nicola R. Poa and
• Paul F. Edgar

Insulin Resistance Is Associated With Hypercortisolemia in Polynesian Patients Treated With Antipsychotic Medication

• Bernard M.Y. Cheung,
• Nelson M.S. Wat,
• Yu Bun Man,
• Sidney Tam,
• G. Neil Thomas,
• Gabriel M. Leung,
• Chun Ho Cheng,
• Jean Woo,
• Edward D. Janus,
• Chu Pak Lau,
• Tai Hing Lam,
• and Karen S.L. Lam

Development of Diabetes in Chinese With the Metabolic Syndrome: A 6-year prospective study

• Flavio E. Hirai,
• Scot E. Moss,
• Barbara E.K. Klein,
• and Ronald Klein

Severe Hypoglycemia and Smoking in a Long-Term Type 1 Diabetic Population: Wisconsin Epidemiologic Study of Diabetic Retinopathy

• Alexander Turchin,
• Maria Shubina,
• and Merri L. Pendergrass

Relationship of Physician Volume With Process Measures and Outcomes in Diabetes

• Richard W. Grant,
• Deborah J. Wexler,
• Alice J. Watson,
• William T. Lester,
• Enrico Cagliero,
• Eric G. Campbell,
• and David M. Nathan

How Doctors Choose Medications to Treat Type 2 Diabetes: A national survey of specialists and academic generalists

• Rachel M. Holt,
• Frank L. Schwartz,
• and Jay H. Shubrook

Diabetes Care in Extended-Care Facilities: Appropriate intensity of care?

• Catherine Kim,
• Brandy Sinco,
• and Edith A. Kieffer

Racial and Ethnic Variation in Access to Health Care, Provision of Health Care Services, and Ratings of Health Among Women With Histories of Gestational Diabetes Mellitus

• A. Marshall McBean and
• Xinhua Yu

The Underuse of Screening Services Among Elderly Women With Diabetes

• Khalida Ismail,
• Kirsty Winkley,
• Daniel Stahl,
• Trudie Chalder,
• and Michael Edmonds

A Cohort Study of People With Diabetes and Their First Foot Ulcer: The role of depression on mortality

• Marga Giménez,
• Eva Aguilera,
• Conxa Castell,
• Nuria de Lara,
• Joana Nicolau,
• and Ignacio Conget

Relationship Between BMI and Age at Diagnosis of Type 1 Diabetes in a Mediterranean Area in the Period of 1990–2004

• Duk-Hee Lee,
• In-Kyu Lee,
• Michael Steffes,
• and David R. Jacobs, Jr.

Extended Analyses of the Association Between Serum Concentrations of Persistent Organic Pollutants and Diabetes

• Peter Wiesli,
• Pierre-Alexandre Krayenbühl,
• Oranna Kerwer,
• Burkhardt Seifert,
• and Christoph Schmid

Maintenance of Glucose Control in Patients With Type 1 Diabetes During Acute Mental Stress by Riding High-Speed Rollercoasters

• Mary de Groot,
• Todd Doyle,
• Erin Hockman,
• Charles Wheeler,
• Brenda Pinkerman,
• Jay Shubrook,
• Robert Gotfried,
• and Frank Schwartz

Depression Among Type 2 Diabetes Rural Appalachian Clinic Attendees

• Julio Rosenstock,
• Priscilla Hollander,
• Kishore M. Gadde,
• Xiang Sun,
• Richard Strauss,
• and Albert Leung

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Topiramate Controlled Release in the Treatment of Obese Type 2 Diabetic Patients

• Dennis Kim,
• Leigh MacConell,
• Dongliang Zhuang,
• Prajakti A. Kothare,
• Michael Trautmann,
• Mark Fineman,
• and Kristin Taylor

Effects of Once-Weekly Dosing of a Long-Acting Release Formulation of Exenatide on Glucose Control and Body Weight in Subjects With Type 2 Diabetes

• Kwang Kon Koh,
• Michael J. Quon,
• Sang Jin Lee,
• Seung Hwan Han,
• Jeong Yeal Ahn,
• Jeong-a Kim,
• Wook-Jin Chung,
• Yonghee Lee,
• and Eak Kyun Shin

Efonidipine Simultaneously Improves Blood Pressure, Endothelial Function, and Metabolic Parameters in Nondiabetic Patients With Hypertension

• Tina Vilsbøll,
• Milan Zdravkovic,
• Tu Le-Thi,
• Thure Krarup,
• Ole Schmitz,
• Jean-Pierre Courrèges,
• Robert Verhoeven,
• Ingrid Bugánová,
• and Sten Madsbad

Liraglutide, a Long-Acting Human Glucagon-Like Peptide-1 Analog, Given as Monotherapy Significantly Improves Glycemic Control and Lowers Body Weight Without Risk of Hypoglycemia in Patients With Type 2 Diabetes

• Haruhiko Osawa,
• Yasuharu Tabara,
• Ryuichi Kawamoto,
• Jun Ohashi,
• Masaaki Ochi,
• Hiroshi Onuma,
• Wataru Nishida,
• Kazuya Yamada,
• Jun Nakura,
• Katsuhiko Kohara,
• Tetsuro Miki,
• and Hideichi Makino

Plasma Resistin, Associated With Single Nucleotide Polymorphism −420, Is Correlated With Insulin Resistance, Lower HDL Cholesterol, and High-Sensitivity C-Reactive Protein in the Japanese General Population

• Seok Won Park,
• Bret H. Goodpaster,
• Elsa S. Strotmeyer,
• Lewis H. Kuller,
• Robert Broudeau,
• Candace Kammerer,
• Nathalie de Rekeneire,
• Tamara B. Harris,
• Ann V. Schwartz,
• Frances A. Tylavsky,
• Yong-wook Cho,
• and Anne B. Newman

Accelerated Loss of Skeletal Muscle Strength in Older Adults With Type 2 Diabetes: The Health, Aging, and Body Composition Study

• Su Chi Lim,
• Nils G. Morgenthaler,
• Tavintharan Subramaniam,
• Yew Seng Wu,
• Siew Kheng Goh,
• and Chee Fang Sum

The Relationship Between Adrenomedullin, Metabolic Factors, and Vascular Function in Individuals With Type 2 Diabetes

• Gemma C. González,
• Ismael Capel,
• José Rodríguez-Espinosa,
• Didac Mauricio,
• Alberto de Leiva,
• and Antonio Pérez

Thyroid Autoimmunity at Onset of Type 1 Diabetes as a Predictor of Thyroid Dysfunction

• Beate Karges,
• Carsten Bergmann,
• Katrina Scholl,
• Eberhard Heinze,
• Franz Maximilian Rasche,
• Klaus Zerres,
• Klaus-Michael Debatin,
• Martin Wabitsch,
• and Wolfram Karges

Digenic Inheritance of Hepatocyte Nuclear Factor-1α and -1β With Maturity-Onset Diabetes of the Young, Polycystic Thyroid, and Urogenital Malformations

• Abel López-Bermejo,
• Javad Khosravi,
• Wifredo Ricart,
• Antoni Castro,
• Vivian Hwa,
• Katherine L. Pratt,
• Roser Casamitjana,
• Ron G. Rosenfeld,
• and José Manuel Fernández-Real

Insulin-Like Growth Factor Binding Protein–Related Protein 1 (IGFBP-rP1/MAC25) Is Linked to Endothelial-Dependent Vasodilation in High-Ferritin Type 2 Diabetes

• Gianluca Perseghin,
• Georgia Ntali,
• Francesco De Cobelli,
• Guido Lattuada,
• Antonio Esposito,
• Elena Belloni,
• Tamara Canu,
• Federica Costantino,
• Francesca Ragogna,
• Paola Scifo,
• Alessandro Del Maschio,
• and Livio Luzi

Abnormal Left Ventricular Energy Metabolism in Obese Men With Preserved Systolic and Diastolic Functions Is Associated With Insulin Resistance

• James Dilley,
• Anbazhagan Ganesan,
• Raj Deepa,
• Mohan Deepa,
• Gopalakrishnan Sharada,
• O. Dale Williams,
• and Viswanathan Mohan

Association of A1C With Cardiovascular Disease and Metabolic Syndrome in Asian Indians With Normal Glucose Tolerance

• Aya Kadota,
• Atsushi Hozawa,
• Tomonori Okamura,
• Takashi Kadowak,
• Koshi Nakmaura,
• Yoshitaka Murakami,
• Takehito Hayakawa,
• Yoshikuni Kita,
• Akira Okayama,
• Yasuyuki Nakamura,
• Atsunori Kashiwagi,
• and Hirotsugu Ueshima

Relationship Between Metabolic Risk Factor Clustering and Cardiovascular Mortality Stratified by High Blood Glucose and Obesity: NIPPON DATA90, 1990–2000

• Paul A. McAuley,
• Jonathan N. Myers,
• Joshua P. Abella,
• Swee Y. Tan,
• and Victor F. Froelicher

Exercise Capacity and Body Mass as Predictors of Mortality Among Male Veterans With Type 2 Diabetes

• Muhammad A. Abdul-Ghani,
• Ken Williams,
• Ralph A. DeFronzo,
• and Michael Stern

What Is the Best Predictor of Future Type 2 Diabetes?

• Jared P. Reis,
• Denise von Mühlen,
• Donna Kritz-Silverstein,
• Deborah L. Wingard,
• and Elizabeth Barrett-Connor

Vitamin D, Parathyroid Hormone Levels, and the Prevalence of Metabolic Syndrome in Community-Dwelling Older Adults

• Chaoyang Li and
• Earl S. Ford

Is There a Single Underlying Factor for the Metabolic Syndrome in Adolescents?: A confirmatory factor analysis

• K.M.V. Narayan,
• James P. Boyle,
• Theodore J. Thompson,
• Edward W. Gregg,
• and David F. Williamson

Effect of BMI on Lifetime Risk for Diabetes in the U.S.

• Hanna D. Margeirsdottir,
• Jakob R. Larsen,
• Cathrine Brunborg,
• Leiv Sandvik,
• and Knut Dahl-Jørgensen

Strong Association Between Time Watching Television and Blood Glucose Control in Children and Adolescents With Type 1 Diabetes

• Johan Wadén,
• Lena M. Thorn,
• Carol Forsblom,
• Timo Lakka,
• Markku Saraheimo,
• Milla Rosengård-Bärlund,
• Outi Heikkilä,
• Maija Wessman,
• Joni A. Turunen,
• Maija Parkkonen,
• Heikki Tikkanen,
• and Per-Henrik Groop

Leisure-Time Physical Activity Is Associated With the Metabolic Syndrome in Type 1 Diabetes: Effect of the PPARγ Pro12Ala polymorphism: the FinnDiane Study

• Qing Ling Duan,
• Marie-Pierre Dubé,
• Nancy Frasure-Smith,
• Amina Barhdadi,
• François Lesperance,
• Pierre Théroux,
• Judith St-Onge,
• Guy A. Rouleau,
• and Jeanne M. McCaffery

Additive Effects of Obesity and TCF7L2 Variants on Risk for Type 2 Diabetes Among Cardiac Patients

• Kelminda Bulhões and
• Leila Araújo

Metabolic Syndrome in Hypertensive Patients: Correlation between anthropometric data and laboratory findings

• Anne G. Niehoff,
• Timon W. van Haeften,
• N. Charlotte Onland-Moret,
• Clara C. Elbers,
• Cisca Wijmenga,
• and Yvonne T. van der Schouw

C-Reactive Protein Is Independently Associated With Glucose but Not With Insulin Resistance in Healthy Men

• Samuel Klein,
• David B. Allison,
• Steven B. Heymsfield,
• David E. Kelley,
• Rudolph L. Leibel,
• Cathy Nonas,
• and Richard Kahn

Waist Circumference and Cardiometabolic Risk: A Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Association

• Moshe Phillip,
• Tadej Battelino,
• Henry Rodriguez,
• Thomas Danne,
• and Francine Kaufman

Use of Insulin Pump Therapy in the Pediatric Age-Group: Consensus statement from the European Society for Paediatric Endocrinology, the Lawson Wilkins Pediatric Endocrine Society, and the International Society for Pediatric and Adolescent Diabetes, endorsed by the American Diabetes Association and the European Association for the Study of Diabetes

• Steven E. Kahn and
• Bernard Zinman

Point: Recent Long-Term Clinical Studies Support an Enhanced Role for Thiazolidinediones in the Management of Type 2 Diabetes

• Ebaa Al-Ozairi,
• Latika Sibal,
• and Philip Home

Counterpoint: A Diabetes Outcome Progression Trial (ADOPT): Good for Sulfonylureas?