Cortisol Secretion in Patients With Type 2 Diabetes: Relationship With Chronic Complications
Response to Castillo-Quan and Pérez-Osorio
- Iacopo Chiodini, MD1,
- Guido Adda, MD2,
- Paolo Beck-Peccoz1,
- Emanuela Orsi, MD1,
- Bruno Ambrosi3 and
- Maura Arosio12
- 1Endocrine Unit, Department of Medical Sciences, University of Milan, Fondazione Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, Italy
- 2Department of Endocrinology, San Giuseppe-Milanocuore Hospital, Fatebenefratelli Research Association, Milan, Italy
- 3Unit of Endocrinology, Department of Medical and Surgical Sciences, University of Milan, IRCCS Policlinico San Donato Institute, San Donato Milanese, Milan, Italy
- Address correspondence to Iacopo Chiodini, MD, Endocrine Unit, Department of Medical Sciences, University of Milan, Fondazione Policlinico, Mangiagalli e Regina Elena, IRCCS, Via Francesco Sforza 35, 20122 Milan, Italy. E-mail: iacopo.chiodini{at}email.it
Several papers focused on the possible link between cortisol secretion and physiological and pathological cerebral aging (1,2). The neurological (mainly limbic-hippocampal) degenerative modification during aging has been suggested to be responsible for a hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis, and an age-related decrease of HPA sensitivity to cortisol feedback has been reported (2).
In our study (3 …
