IGF-Binding Protein-1 Levels Are Related to Insulin-Mediated Glucose Disposal and Are a Potential Serum Marker of Insulin Resistance
Response to Maddux et al.
- Timon W. van Haeften, MD1,
- Maria L. Zonderland, PHD2,
- Louise W.E. Sabelis, MD3 and
- Jaap van Doorn, PHD4
- 1Department of Internal Medicine, University Medical Center, Utrecht, the Netherlands
- 2Department of Medical Physiology, University Medical Center Utrecht, Utrecht, the Netherlands
- 3Department of Rehabilitation Medicine, Academic Medical Center Amsterdam, Amsterdam, the Netherlands
- 4Department of Metabolic and Endocrine Diseases, University Center Utrecht, Utrecht, the Netherlands
- Address correspondence to Dr. T.W. van Haeften, Department of Internal Medicine F02.126, University Medical Center Utrecht, P.O. Box 85500, NL 3508 GA Utrecht, Netherlands. E-mail: t.w.vanhaeften{at}umcutrecht.nl
We were interested in the article of Maddux et al. (1) in which they found a correlation coefficient of 0.75 for the relationship of IGF-binding protein (IGFBP)-1 with insulin sensitivity. Often, the homeostasis model assessment of insulin resistance (HOMA-IR) or other assessments such as the Stumvoll Index (2) are used. Because hepatic production of IGFBP-1 is under direct inhibitory influence of insulin, plasma IGFBP-1 levels could potentially be of use …
