Postprandial Hyperglycemia Is Associated With an Increase of Blood Pressure in Type 1 Diabetic Patients Treated With Continuous Subcutaneous Insulin Infusion
- Giuseppe Lepore, MD,
- Anna Corsi, MD,
- Alessandro R. Dodesini, MD,
- Italo Nosari, MD and
- Roberto Trevisan, MD, PHD
- From the Diabetes Unit, Azienda Ospedaliera Ospedali Riuniti, Bergamo, Italy
- Address correspondence to Dr. Giuseppe Lepore, Diabetes Unit, A.O. Ospedali Riuniti, Largo Barozzi, 1, 24128 Bergamo, Italy. E-mail: glepore{at}ospedaliriuniti.bergamo.it
Blood pressure normally decreases after a meal and reaches a nadir between 30 and 60 min after eating (1). Giugliano et al. (2) showed that acute hyperglycemia in normal subjects significantly increases systolic and diastolic blood pressure. To define the relationship between postprandial plasma glucose excursions and blood pressure variations in type 1 diabetes, we studied 10 normotensive, type 1 diabetic patients (mean ± SD age 39.7 ± 16.7 years, diabetes duration 10.5 ± 5.4 years, A1C 7.4 ± 0.8%, and BMI 23.9 ± 3.5 kg/m2) without microangiopatic complications. All patients were in therapy with continuous subcutaneous insulin infusion. None took any hypotensive drug. …
