Total and High–Molecular Weight Adiponectin in Relation to Metabolic Variables at Baseline and in Response to an Exercise Treatment Program: Comparative Evaluation of Three Assays
Response to Blüher et al.
- Maximilian von Eynatten, MD1,
- Philipp M. Lepper, MD2 and
- Per M. Humpert, MD3
- 1Department of Nephrology, Technical University Munich, Ismaningerstr, Munich, Germany
- 2Department of Intensive Care Medicine, University of Bern, Bern, Switzerland
- 3Department of Medicine I and Clinical Chemistry, Heidelberg University, Im Neuenheimer Feld, Heidelberg, Germany
- Address correspondence to Maximilian von Eynatten, Department of Nephrology, Technical University Munich, Ismaningerstr 22, 81675 Munich, Germany. E-mail: maximilian.eynatten{at}lrz.tum.de
Recently, increasing attention has been paid to the relationship between multimeric forms of adiponectin and metabolic variables to assess the metabolic significance of high–molecular weight (HMW) adiponectin. Blüher et al. (1) investigated associations between total adiponectin and HMW with insulin resistance and the metabolic syndrome. The study did not demonstrate the superiority of HMW over total adiponectin in assessing insulin sensitivity that was previously reported in larger groups (2,3).
We studied 328 Caucasian men and women (114 non–insulin-resistant, 101 insulin-resistant, and …
