Acute Insulin Response and β-Cell Compensation in Normal Subjects Treated With Olanzapine or Risperidone for 2 Weeks
Response to Hardy et al.
- Ripu D. Jindal, MD
- From the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
- Address correspondence to Ripu D. Jindal, MD, 3811 O'Hara St., Pittsburgh, PA 15213. E-mail: jindalr{at}upmc.edu
Hardy et al. (1) demonstrate that administration of olanzapine or risperidone does not impair acute insulin response and conclude that their results argue against substantial and generalized impairment of insulin action secretion with these agents after short-term treatment. An earlier study by Ader et al. (2) suggested that olanzapine impairs insulin sensitivity as well as compensatory increase in insulin secretion. Hardy et al. (1) acknowledge that …
