Prospective Study of Hyperglycemia and Cancer Risk
Response to Bowker and Johnson
- Pär Stattin, MD, PHD1,
- Annekatrin Lukanova, MD, PHD23,
- Bernt Lindahl, MD, PHD4,
- Göran Hallmans, MD, PHD3 and
- Rudolf Kaaks, PHD2
- 1Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University Hospital, Umeå, Sweden
- 2Division of Cancer Epidemiology, German Cancer Research Center Neuenheimer, Heidelberg, Germany
- 3Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University Hospital, Umeå, Sweden
- 4Department of Public Health and Clinical Medicine, Behavorial Medicine, Umeå University Hospital, Umeå, Sweden
- Address correspondence to Pär Stattin, Deptartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University Hospital, 901 85 Umeå, Sweden. E-mail: par.stattin{at}urologi.umu.se
There are many possible mechanisms underlying the association between hyperglycemia and cancer risk (1); however, they were not discussed in our recent article (2), due to format limitations. At a cellular level, glucose may lead to activation of energy sensing mechanisms, which in turn favor cellular growth and proliferation. Additionally, elevated glucose concentrations may also stimulate cancer growth through increased formation of advanced glycation end products. As noted by Bowker and Johnson (3), increased …
