Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test
Response to Abdul-Ghani et al.
- Jean-Philippe Bastard, MD, PHD123,
- May Faraj, PHD4,
- Antony D. Karelis, PHD4,
- Jennifer Lavasseur, BSC4,
- Dominique Garrel, MD4,
- Denis Prud'homme, PHD5 and
- Rémi Rabasa-Lhoret, MD, PHD46
- 1AP-HP, Hôpital Hôpital Tenon, Service de Biochimie et Hormonologie, Paris, France
- 2INSERM, U680, Paris, France
- 3Faculté de Médecine, Université Pierre et Marie Curie-Paris 6, UMRS680, Paris, France
- 4Laboratoire des Dysfonctions Métaboliques, Department of Nutrition, Université de Montréal, Montreal, Quebec, Canada
- 5School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
- 6Centre de Recherche du Centre Hospitalier de L'Université de Montréal, Montréal Québec
- Address correspondence to Rémi Rabasa-Lhoret, MD, PhD, Département of Nutrition, Université de Montréal, Montréal, Québec, Canada. E-mail: remi.rabasa-lhoret{at}umontreal.ca
It was recently reported (1) that it is important to assess both hepatic and muscle insulin resistance because doing so can lead to different treatment approaches according to the insulin resistance status of each organ. Currently, the hyperinsulinemic-euglycemic clamp is the gold standard for the measurement of liver and muscle insulin sensitivity (2). However, this method is unpractical in clinical practice. For this reason, Abdul-Ghani et al. (1) developed several formulas that were derived from an oral glucose tolerance test (OGTT) for the assessment of …
