Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test
Response to Bastard et al.
- Muhammad A Abdul-Ghani, MD, PHD,
- Masafumi Matsuda, MD,
- Bogdan Balas, MD and
- Ralph A. DeFronzo, MD
- From the Division of Diabetes, University of Texas Health Science Center, San Antonio, Texas
- Address correspondence to Ralph A. DeFronzo, MD, Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Dr., San Antonio, TX 78229. E-mail: albarado{at}uthscsa.edu
Bastard et al. (1,2) have examined the correlation between the oral glucose tolerance test (OGTT)-derived muscle insulin resistance index and the total glucose disposal divided by the steady-state plasma insulin concentration (TGD/SSPI) during the euglycemic insulin clamp in obese postmenopausal women and reported a lower correlation coefficient (2) compared with that reported earlier in a more heterogeneous population (3). Further, the correlation between the OGTT-derived muscle insulin resistance index (3) and TGD/SSPI was not significantly …
