Bone Size Normalizes With Age in Children and Adolescents With Type 1 Diabetes

  1. Susanne Bechtold, MD,
  2. Stefanie Putzker, MD,
  3. Walter Bonfig, MD,
  4. Oliver Fuchs, MD,
  5. Isa Dirlenbach, MD and
  6. Hans Peter Schwarz, MD, PHD
  1. From the Division of Pediatric Endocrinology, University Children's Hospital, Munich, Germany
  1. Address correspondence and reprint requests to Susanne Bechtold, MD, University Children's Hospital, Lindwurmstrasse 4 in D-80337, Munich, Germany. E-mail: susanne.bechtold{at}med.uni-muenchen.de

Abstract

OBJECTIVE—The aim of this study was to establish whether type 1 diabetes has a long-term effect on bone development in children and adolescents.

RESEARCH DESIGN AND METHODS—Bone characteristics and muscle cross-sectional area (CSA) were analyzed cross-sectionally in 41 (19 female and 22 male) patients and were reevaluated after 5.56 ± 0.4 years using peripheral quantitative computed tomography (pQCT). We hypothesize that bone size and muscle mass normalize with age.

RESULTS—At the first evaluation, mean ± SD age was 9.87 ± 2.3 years and disease duration was 4.31 ± 2.9 years. Height was −0.36 ± 1.9 SD, and BMI was 0.39 ± 0.9 SD. Parameters of bone size were low in the whole patient group (corrected for patient's height). At reevaluation, age was 15.44 ± 2.3 years, and patients had a mean height of −0.12 ± 0.8 SD. BMI SD had increased to 0.57 ± 1.1. Total and cortical CSA had normalized. Those patients with an increase in total CSA had a significant younger age at disease manifestation and a younger age at initial pQCT measurement. Bone size was well adapted to muscle mass expressed as the ratio of bone mineral content per muscle mass, and a close correlation was shown between the increase in bone size and in muscle CSA (r = 0.46, P = 0.03).

CONCLUSIONS—Patients with manifestation of type 1 diabetes at an early age had transient impaired bone development. Within the follow-up period, the greatest increase in bone size was found in these patients. In adolescence, all patients had a normal bone size and appropriate adaptation of bone on muscle.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 24 April 2007. DOI: 10.2337/dc07-0142.

    A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted April 29, 2007.
    • Received January 24, 2007.
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  1. Diabetes Care vol. 30 no. 8 2046-2050
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