Accuracy and Predictive Value of Classification Schemes for Ketosis-Prone Diabetes
Response to Balasubramanyam et al.
- Cristian Fernández, MD,
- Marga Giménez, MD,
- Gonzalo Díaz, MD and
- Ignacio Conget, MD, PHD
- Endocrinology and Diabetes Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic i Universitari, Barcelona, Spain
- Address correspondence to Dr. I. Conget, Endocrinology and Diabetes Unit, Villarroel 170, 08036 Barcelona, Spain. E-mail: iconget{at}clinic.ub.es
We have read with interest the study by Balasubramanyam et al. (1). They described a new classification scheme (Aβ classification) based on C-peptide levels and the presence or absence of β-cell autoantibodies to predict long-term β-cell function and insulin independence in patients who presented with diabetic ketoacidosis (DKA). They reported a sensitivity of 99.4%, a specificity of 95.9%, and a positive likelihood ratio (LR) of 24.55 in the total cohort of 294 subjects. In the subset of 138 subjects presenting with DKA as new-onset diabetes, 99.1%, 95.5%, and 21.79 sensitivity, specificity, and positive LR, respectively, were observed.
To evaluate the performance of this new classification in a Caucasian-Spanish population, 40 consecutive adult …
