Effect of Cinnamon on Glucose Control and Lipid Parameters

  1. William L. Baker, PHARMD, BCPS12,
  2. Gabriela Gutierrez-Williams, PHARMD2,
  3. C. Michael White, PHARMD, FCP, FCCP12,
  4. Jeffrey Kluger, MD3 and
  5. Craig I. Coleman, PHARMD12
  1. 1Department of Pharmacy Practice, School of Pharmacy, University of Connecticut, Storrs, Connecticut
  2. 2Department of Drug Information, Hartford Hospital, Hartford, Connecticut
  3. 3Department of Cardiology, Hartford Hospital, Hartford, Connecticut
  1. Address correspondence and reprint requests to Craig I. Coleman, Pharm D, Assistant Professor of Pharmacy Practice, University of Connecticut, Hartford Hospital, 80 Seymour St., Hartford, CT 06102-5037. E-mail: ccolema{at}harthosp.org

Abstract

OBJECTIVE—To perform a meta-analysis of randomized controlled trials of cinnamon to better characterize its impact on glucose and plasma lipids.

RESEARCH DESIGN AND METHODS—A systematic literature search through July 2007 was conducted to identify randomized placebo-controlled trials of cinnamon that reported data on A1C, fasting blood glucose (FBG), or lipid parameters. The mean change in each study end point from baseline was treated as a continuous variable, and the weighted mean difference was calculated as the difference between the mean value in the treatment and control groups. A random-effects model was used.

RESULTS—Five prospective randomized controlled trials (n = 282) were identified. Upon meta-analysis, the use of cinnamon did not significantly alter A1C, FBG, or lipid parameters. Subgroup and sensitivity analyses did not significantly change the results.

CONCLUSIONS—Cinnamon does not appear to improve A1C, FBG, or lipid parameters in patients with type 1 or type 2 diabetes.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 1 October 2007. DOI: 10.2337/dc07-1711.

    A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted September 28, 2007.
    • Received August 29, 2007.
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  1. Diabetes Care vol. 31 no. 1 41-43
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