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Diabetes and Obesity-Related Risks for Pelvic Reconstructive Surgery in a Cohort of Swedish Twins

  1. Mats Forsman, MSC1,
  2. Anastasia Iliadou, PHD1,
  3. Patrik Magnusson, PHD1,
  4. Christian Falconer, MD, PHD2 and
  5. Daniel Altman, MD, PHD12
  1. 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  2. 2Division of Obstetrics and Gynecology, Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
  1. Corresponding author: Daniel Altman, daniel.altman{at}ki.se

Abstract

OBJECTIVE—To determine the diabetes- and obesity-related risks for surgically managed stress urinary incontinence and pelvic organ prolapse.

RESEARCH DESIGN AND METHODS—This twin cohort study used the Swedish Twin Register to identify 8,443 female twin pairs born from 1926 through 1958. The association between diabetes and pelvic floor surgery was estimated while taking into account the correlated (twin) structure of the data.

RESULTS—For type 1 and type 2 diabetes, no significant associations were observed for stress urinary incontinence (odds ratio [OR] 1.0 [95% CI 0.1–9.2] and 2.0 [1.0–4.0], respectively). There were no cases of prolapse surgery in type 1 diabetic subjects, and for type 2 diabetes the risk estimate was nonsignificant (1.6 [1.0–2.7]). BMI >25 kg/m2, age ≥60 years, and childbirth were the strongest risk factors for having incontinence surgery.

CONCLUSIONS—Our data suggest that diabetes is not associated with stress urinary incontinence or pelvic organ prolapse surgery.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 15 July 2008.

    C.F. is a consultant for Gynecare and a lecturer for Astellas and Pfizer. D.A. is a consultant for Gynecare and a lecturer for Astellas.

    Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted June 30, 2008.
    • Received May 29, 2008.
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This Article

  1. Published online before print July 15, 2008, doi: 10.2337/dc08-0988 Diabetes Care October 2008 vol. 31 no. 10 1997-1999
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