Pancreas Histology and a Longitudinal Study of Insulin Secretion in a Japanese Patient With Latent Autoimmune Diabetes in Adults
- Satoshi Murao, MD, PHD1,
- Akihisa Imagawa, MD, PHD2,
- Eiji Kawasaki, MD, PHD3,
- Kazuaki Yokota, MD, PHD1,
- Tetsuji Yamashita, MD, PHD1,
- Takashi Sekikawa, MD, PHD1,
- Haruhiko Osawa, MD, PHD4,
- Toshiaki Hanafusa, MD, PHD2 and
- Hideichi Makino, MD, PHD5
- 1Department of Internal Medicine, Matsuyama Shimin Hospital, Ehime, Japan
- 2First Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan
- 3Department of Metabolism/Diabetes & Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
- 4Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
- 5Diabetes Research Center, Takanoko Hospital, Ehime, Japan
- Corresponding author: Satoshi Murao, sat.murao{at}gmail.com
Positive islet cell–related autoantibody is thought to reflect the process of immune-mediated β-cell damage symbolized by the insulitis, but there have been few reports on the pancreas histology of latent autoimmune diabetes in adults (LADA). We report a study of pancreas histology and a longitudinal insulin secretion in a LADA patient.
A 50-year-old woman treated with sulfonylurea from the age of 40 years was referred to our hospital in 1999. On the first visit, she was prescribed 5 mg/day glibenclamide. Her BMI was 18.2 kg/m2; her maximum BMI at age 40 years, was 26.5 kg/m2; her A1C was 7.8%. She was positive for GAD antibody (titer …
