Predictive Value of Postoperative Glycosuria After Partial Elective Pancreatectomy in Focal Congenital Hyperinsulinism
- Naziha Khen-Dunlop, MD12,
- Carmen Capito, MD1,
- Vassili Valayannopoulos, MD3,
- Caroline Elie, MD24,
- Maria-Joao Ribeiro, MD5,
- Jacques Rahier, PHD6,
- Francis Jaubert, PHD7,
- Jean-Jacques Robert, PHD3,
- Yves Aigrain, MD1,
- Pascale de Lonlay, PHD3 and
- Claire N. Fékété, MD1
- 1Department of Pediatric Surgery, Necker–Enfants Malades Hospital, Paris, France
- 2Paris Descartes University, Paris, France
- 3Department of Pediatrics, Necker-Enfants Malades Hospital, Paris, France
- 4Department of Biostatistics, Necker-Enfants Malades Hospital, Paris, France
- 5Department of Medical Research, Commissariat a l’Energie Atomique, Orsay, France
- 6Department of Pathology, Cliniques Universitaires St. Luc, Louvain University, Brussels, Belgium
- 7Department of Pathology, Necker–Enfants Malades Hospital, Paris, France
- Corresponding author: Naziha Khen-Dunlop, naziha.khen-dunlop{at}nck.aphp.fr
Congenital hyperinsulinism (CHI) is the most frequent cause of persistent hypoglycemia in infants (1). Early diagnosis and management are mandatory to prevent permanent brain damage. Two main forms are distinguished based on anatomical and genetic characteristics: the focal and the diffuse forms (2). In focal forms, the complete removal of the lesion allows the cure of the disease, but residual affected tissue may be left behind. This situation, observed in about 15% of cases, often necessitates additional surgery (3). We evaluated the value of detecting postoperative glycosuria as a predictor of successful surgery for focal CHI.
The study included 51 children operated on for focal …
