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Prediction of Mortality Using Measures of Cardiac Autonomic Dysfunction in the Diabetic and Nondiabetic Population: The MONICA/KORA Augsburg Cohort Study

Response to Salvi et al.

  1. Dan Ziegler, MD, PHD, FRCP and
  2. for the KORA Study Group
  1. From the Institut für Klinische Diabetologie, Deutsches Diabetes-Zentrum, Düsseldorf, Germany
  1. Corresponding author: Dan Ziegler, dan.ziegler{at}ddz.uni-duesseldorf.de

We thank Salvi et al. (1) for their interest in our study (2). While there is no doubt that a number of diseases and drugs may contribute to corrected QT (QTc) interval prolongation, cardiac autonomic neuropathy (CAN) has been identified as one of these contributing factors. CAN is 2.3 times (95% CI 1.9–2.7) more likely to be present in diabetic patients with than in those without QTc prolongation (2). Recently, a reasonable …

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