Comparison of Negative Pressure Wound Therapy Using Vacuum-Assisted Closure With Advanced Moist Wound Therapy in the Treatment of Diabetic Foot Ulcers: A Multicenter Randomized Controlled Trial
Response to Blume et al.
- From the Institute for Evidence-Based Medicine (DIeM), Cologne, Germany
- Corresponding author: Lars G. Hemkens, l.hemkens{at}di-em.de
We have read with interest the article by Blume et al. (1) in which the authors interpret the presented results as supporting evidence that negative pressure wound therapy (NPWT) is as safe as and more efficacious than advanced moist wound therapy (AMWT) to treat foot ulcers in diabetic patients. NPWT is widely applied, although the evidence base is weak and existing trials are frequently affected by methodological flaws (2,3). In our opinion, the presented results should be interpreted with more caution.
One of the major reasons for the limited validity of the results is the high proportion of censored subject data (33%, n = 111) in this unblinded trial. Even though …
