Prognostic Value of the Insertion/Deletion Polymorphism of the ACE Gene in Type 2 Diabetic Subjects: Results From the Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR), Diabete de type 2, Nephropathie et Genetique (DIAB2NEPHROGENE), and Survie, Diabete de type 2 et Genetique (SURDIAGENE) Studies
Response to Hadjadj et al.
- Daniel P.K. Ng, PHD
- From the Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
- Corresponding author: Daniel P.K. Ng, cofnpkd{at}nus.edu.sg
Hadjadj et al. (1) have recently reported on the potential prognostic value of the ACE insertion/deletion (ACE I/D) polymorphism in their study of Caucasians with type 2 diabetes. The ACE II genotype contributed to the development of end-stage renal failure (ESRF) in their main cohort analyses of patients from the Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR) study (P = 0.034) (1). This finding was somewhat surprising because the II genotype, which has been linked to lower serum ACE levels, has previously been associated with protection against diabetic nephropathy (2,3). Particularly, a meta-analysis …
