Normal Glucose Values Are Associated With a Lower Risk of Mortality in Hospitalized Patients

  1. Alberto Bruno, MD1,
  2. Dario Gregori, PHD2,
  3. Antonio Caropreso, BD3,
  4. Fulvio Lazzarato4,
  5. Michele Petrinco2 and
  6. Eva Pagano4
  1. 1Diabetologia ASO San Giovanni Battista of Turin, Turin, Italy
  2. 2Department of Public Health and Microbiology, University of Turin, Turin, Italy
  3. 3Central Laboratory ASO San Giovanni Battista of Turin, Turin, Italy
  4. 4Unit of Cancer Epidemiology, CPO Piemonte, University of Turin, Turin, Italy
  1. Corresponding author: Alberto Bruno, abruno{at}molinette.piemonte.it

Abstract

OBJECTIVE—Hyperglycemia is a common condition in hospitalized patients. The aim of this study was to investigate the relationships between glycemia upon admission and mortality in a heterogeneous group of adult patients.

RESEARCH DESIGN AND METHODS—The 3-year records released from a general hospital were associated with a plasma glucose dataset of its general laboratory. A matched case-control study was implemented (3,338 case-control subject pairs). All-patient refined diagnosis–related groups and the relative risk of death were the matching criteria. A multivariate conditional logistic regression model was used to evaluate the associations between death and glycemia.

RESULTS—Higher in-hospital mortality was associated with hyperglycemia or hypoglycemia, whereas lower risk was observed for values between 78 and 101 mg/dl.

CONCLUSIONS—Our data confirm the relation between glycemia upon admission and mortality and suggest that slightly increased or decreased plasma glucose can be linked with increased mortality risk.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 20 August 2008.

    Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted August 11, 2008.
    • Received April 11, 2008.
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  1. Published online before print August 20, 2008, doi: 10.2337/dc08-0672 Diabetes Care November 2008 vol. 31 no. 11 2209-2210
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