Differential Effects of Two Isoenergetic Meals Rich in Saturated or Monounsaturated Fat on Endothelial Function in Subjects With Type 2 Diabetes

  1. Nicholas Tentolouris, MD1,
  2. Christina Arapostathi, MD1,
  3. Despoina Perrea, PHD2,
  4. Despoina Kyriaki, MD1,
  5. Constantinos Revenas, MD1 and
  6. Nicholas Katsilambros, MD1
  1. 1First Department of Propaedeutic Medicine, Laiko General Hospital, Athens University Medical School, Athens, Greece
  2. 2Department of Experimental Surgery and Surgical Research, Athens University Medical School, Athens, Greece
  1. Corresponding author: Nicholas Tentolouris, ntentol{at}med.uoa.gr

Abstract

OBJECTIVE—To examine the acute effects of consumption of monounsaturated (MUFAs) and saturated fatty acids (SAFAs) on endothelial function in subjects with type 2 diabetes.

RESEARCH DESIGN AND METHODS—A total of 33 participants were examined after consumption of two different isocaloric meals: one rich in MUFA and one rich in SAFA, in the form of extra-virgin olive oil and butter, respectively. Endothelial function was assessed by determination of flow-mediated dilatation (FMD).

RESULTS—FMD did not change significantly after the MUFA-rich meal but declined after the SAFA-rich meal. The FMD during the experiment, expressed as incremental area under the curve, increased after the MUFA-rich meal by 5.2 ± 2.5% and decreased after the SAFA-rich meal by 16.7 ± 6.0% (Δ = −11.5 ± 6.4%; P = 0.008).

CONCLUSIONS—Consumption of an SAFA-rich meal is harmful for the endothelium, while a MUFA-rich meal does not impair endothelial function in subjects with type 2 diabetes.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 3 October 2008.

    Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    • Accepted September 2, 2008.
    • Received May 19, 2008.
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  1. Published online before print October 3, 2008, doi: 10.2337/dc08-0924 Diabetes Care December 2008 vol. 31 no. 12 2276-2278
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