Zinc Intake and Biochemical Markers of Bone Turnover in Type 1 Diabetes

  1. Raelene E. Maser, PHD12,
  2. John N. Stabley, MS3,
  3. M. James Lenhard, MD2,
  4. Phyllis Owusu-Griffin, MD2,
  5. Michelle A. Provost-Craig, PHD3 and
  6. William B. Farquhar, PHD3
  1. 1Department of Medical Technology, University of Delaware, Newark, Delaware
  2. 2Diabetes and Metabolic Research Center, Christiana Care Health Services, Newark, Delaware
  3. 3Department of Health, Nutrition, and Exercise Sciences, University of Delaware, Newark, Delaware
  1. Corresponding author: Raelene E. Maser, rmaser{at}udel.edu

Abstract

OBJECTIVE—To examine the relationship between Zn nutritive status and biochemical markers of bone turnover in type 1 diabetes.

RESEARCH DESIGN AND METHODS—Serum osteocalcin, urine N-telopeptides, and dietary intake data, obtained by 3-day food records, were assessed for 66 individuals with type 1 diabetes.

RESULTS—Zn intake correlated with osteocalcin in the group overall (r = 0.48; P < 0.001) but not with N-telopeptides. Examined by sex, both Zn and osteocalcin correlated for men (r = 0.57; P < 0.001), but the correlation did not reach statistical significance for women (r = 0.34; P = 0.09). A direct-entry linear regression model with osteocalcin as the dependent variable was performed. Duration, sex, A1C, insulin use per kilogram, total calorie intake, and Zn intake were entered as potential independent variables. The model was statistically significant (R2 = 0.32; P < 0.01). Zn intake (P < 0.001), however, was the only independent correlate of osteocalcin.

CONCLUSIONS—This study provides evidence of a positive relationship between Zn intake and osteocalcin in type 1 diabetes.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 22 September 2008.

    Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    • Accepted September 2, 2008.
    • Received June 12, 2008.
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  1. Published online before print September 22, 2008, doi: 10.2337/dc08-1068 Diabetes Care December 2008 vol. 31 no. 12 2279-2280
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