Glimepiride-Induced Bronchial Asthma
Case report
- Kazuhisa Tsukamoto, MD, PHD,
- Keisuke Ohta, MD,
- Ryo Suzuki, MD, PHD,
- Masumi Hara, MD, PHD,
- Jun-ichi Osuga, MD, PHD,
- Kazuyuki Tobe, MD, PHD and
- Takashi Kadowaki, MD, PHD
- From the Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
- Corresponding author: Kazuhisa Tsukamoto, kazuhisa-tky{at}umin.ac.jp
A 40-year-old woman who suffered from type 2 diabetes but had no allergies or history of asthma appeared in the outpatient clinic due to dyspnea. She had been diagnosed with diabetes in 2000, and pioglitazone and buformin were initiated in August and December 2004, respectively. However, because her A1C level was still elevated (8.2%), glimepiride (1 mg/day) was added on 3 August 2005. Two hours after taking the medication, she manifested general malaise, and in the evening, further developed wheezing and dyspnea. Her symptoms worsened gradually, compelling her to visit the outpatient clinic on 4 August 2005. The physical examination revealed stridor upon chest auscultation. An arterial blood gas test revealed hypoxemia (PaO …
