Detection of a Meal Using Continuous Glucose Monitoring
Implications for an artificial β-cell
- Eyal Dassau, PHD1,
- B. Wayne Bequette, PHD2,
- Bruce A. Buckingham, MD3 and
- Francis J. Doyle III, PHD1
- 1Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California
- 2Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York
- 3Stanford Medical Center, Stanford, California
- Address correspondence and reprint requests to Francis J. Doyle III, Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106-5080. E-mail: frank.doyle{at}icb.ucsb.edu
Abstract
OBJECTIVE—The purpose of this study was to introduce a novel meal detection algorithm (MDA) to be used as part of an artificial β-cell that uses a continuous glucose monitor (CGM).
RESEARCH DESIGN AND METHODS—We developed our MDA on a dataset of 26 meal events using records from 19 children aged 1–6 years who used the MiniMed CGMS Gold. We then applied this algorithm to CGM records from a DirecNet pilot study of the FreeStyle Navigator continuous glucose sensor. During a research center admission, breakfast insulin was withheld for 1 h, and discrete glucose levels were obtained every 10 min after the meal.
RESULTS—Based on the Navigator readings, the MDA detected a meal at a mean time of 30 min from the onset of eating, at which time the mean serum glucose was 21 mg/dl above baseline (range 2–36 mg/dl), and >90% of meals were detected before the glucose had risen 40 mg/dl from baseline.
CONCLUSIONS—The MDA will enable automated insulin dosing in response to meals, facilitating the development of an artificial pancreas.
Footnotes
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Published ahead of print at http://care.diabetesjournals.org on 31 October 2007. DOI: 10.2337/dc07-1293.
B.W.B. serves on the Scientific Advisory Board of Ultradian Diagnostics. B.A.B. has received honoraria as a speaker for Abbott Diabetes Care.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Accepted October 21, 2007.
- Received July 6, 2007.
- DIABETES CARE
