Squatting Amplifies Pulse Pressure Increase With Disease Duration in Patients With Type 1 Diabetes
- Jean-Christophe Philips, MD,
- Monique Marchand and
- André J. Scheen, MD, PHD
- From the 1Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, Centre Hospitalier Universitaire Sart Tilman, University of Liége, Liège, Belgium
- Address correspondence and reprint requests to André J. Scheen, Diabetes, Nutrition and Metabolic Disorders Unit, C.H.U. Sart Tilman (B35), Liege 1 B-4000,Belgium. E-mail: andre.scheen{at}chu.ulg.ac.be
Abstract
OBJECTIVE—To evaluate pulse pressure changes according to duration of type 1 diabetes and to assess the influence of posture.
RESEARCH DESIGN AND METHODS—We performed continuous measurement of blood pressure with a Finapres device during a 3 × 1 min posture test (standing, squatting, standing) in 159 type 1 diabetic patients divided into four groups according to diabetes duration (≤10, 11–20, 21–30, and >30 years, groups 1–4, respectively) and compared the results with those of age-matched nondiabetic subjects.
RESULTS—Pulse pressure progressively increased according to type 1 diabetes duration (P < 0.0001), especially in women, but not in age-matched nondiabetic subjects (NS). Pulse-pressure increase from group 1 to group 4 was amplified in the squatting position (from 50 ± 17 to 69 ± 14 mmHg) compared with standing (from 44 ± 15 to 55 ± 12 mmHg).
CONCLUSIONS—Pulse pressure increases according to type 1 diabetes duration more in women than in men, and the squatting position sensitizes such pulse-pressure increase in both sexes.
Footnotes
-
Published ahead of print at http://care.diabetesjournals.org on 31 October 2007. DOI: 10.2337/dc07-1646.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.
-
- Accepted October 24, 2007.
- Received August 21, 2007.
- DIABETES CARE
