High Serum Uric Acid as a Novel Risk Factor for Type 2 Diabetes

  1. Abbas Dehghan, MD, DSC1,
  2. Mandy van Hoek, MD2,
  3. Eric J.G. Sijbrands, MD, PHD2,
  4. Albert Hofman, MD, PHD1 and
  5. Jacqueline C.M. Witteman, PHD1
  1. 1Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, the Netherlands
  2. 2Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands
  1. Address correspondence and reprint requests to Dr. J.C.M. Witteman, PhD, Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, Netherlands. E-mail: j.witteman{at}erasmusmc.nl


OBJECTIVE—To investigate the association between serum uric acid level and risk of type 2 diabetes.

RESEARCH DESIGN AND METHODS—The population for analysis consisted of 4,536 subjects free from diabetes at baseline. During a mean of 10.1 years of follow-up, 462 subjects developed diabetes.

RESULTS—The age- and sex-adjusted hazard ratios (HRs) (95% CIs) for diabetes were 1.30 (0.96–1.76) for the second, 1.63 (1.21–2.19) for the third, and 2.83 (2.13–3.76) for the fourth quartile of serum uric acid, in comparison with the first quartile. After adjustment for BMI, waist circumference, systolic and diastolic blood pressure, and HDL cholesterol, the HRs decreased to 1.08 (0.78–1.49), 1.12 (0.81–1.53), and 1.68 (1.22–2.30), respectively.

CONCLUSIONS—The results of this population-based study suggest that serum uric acid is a strong and independent risk factor for diabetes.


  • Published ahead of print at http://care.diabetesjournals.org on 31 October 2007. DOI: 10.2337/dc07-1276.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted October 23, 2007.
    • Received July 6, 2007.
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  1. Diabetes Care vol. 31 no. 2 361-362
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