Neurovascular Factors in Wound Healing in the Foot Skin of Type 2 Diabetic Subjects
Response to Catrina and Brismar
- Singhan T.M. Krishnan, MD and
- Gerry Rayman, FRCP, MD
- From the Diabetes Centre, Ipswich Hospital, Ipswich, U.K
- Address correspondence to Dr. G. Rayman, MD, FRCP, Ipswich Diabetes Centre, Ipswich Hospital NHS Trust, Heath Road, Ipswich, IP4 5PD, U.K. E-mail: gerry.rayman{at}ipswichhospital.nhs.uk
We agree with Catrina and Brismar (1) that the main stimulus for hypoxia-inducible factor-1α (HIF-1α) is hypoxia. Thus, in view of the normal blood vessel density, one would not expect hypoxia, which would be compatible with the normal …
