Metabolic and Immunological Features of the Failing Islet-Transplanted Patient

  1. Paolo Fiorina, MD, PHD12,
  2. Andrea Vergani, MD12,
  3. Alessandra Petrelli, MD1,
  4. Francesca D'Addio, MD2,
  5. Lucilla Monti, MD1,
  6. Reza Abdi, MD2,
  7. Emanuele Bosi, MD1,
  8. Paola Maffi, MD1 and
  9. Antonio Secchi, MD13
  1. 1Department of Medicine, San Raffaele Scientific Institute, Milan, Italy
  2. 2Transplantation Research, Children's Hospital/Brigham and Women's Hospital, Boston, Massachusetts
  3. 3Università Vita e Salute-San Raffaele, Milan, Italy
  1. Address correspondence and reprint requests to Antonio Secchi, MD, Medicine San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milano, Italy. E-mail: antonio.secchi{at}hsr.it

Abstract

OBJECTIVE—This retrospective study was designed to identify metabolic and immune predictors of early islet allograft failure.

RESEARCH DESIGN AND METHODS—We measured several metabolic and immunological markers at the time of pretransplant and several time points posttransplantation in 17 patients with long-term functioning graft (long fx) and 20 patients with short-term functioning graft (short fx).

RESULTS—The short fx group showed higher insulin resistance, altered proinsulin processing, lower soluble interleukin-2 receptor (sIL-2r) (marker of T-cell activation), and higher soluble FasL (marker of apoptosis) during the entire follow-up, particularly at time of failure.

CONCLUSIONS—Patients who experienced an early failure of islet allograft showed specific metabolic and immunological signs long before islet failure.

Footnotes

  • Published ahead of print at http://care.diabetes.journals.org on 10 December 2007. DOI: 10.2337/dc07-1831.

    Additional information for this article can be found in an online appendix at http://dx.doi.org/10.2337/dc07-1831.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    • Accepted November 29, 2007.
    • Received September 18, 2007.
« Previous | Next Article »Table of Contents

This Article

  1. Published online before print December 10, 2007, doi: 10.2337/dc07-1831 Diabetes Care March 2008 vol. 31 no. 3 436-438
  1. » Abstract
  2. Full Text
  3. Full Text (PDF)
  4. Online-Only Appendix
  5. Online-Only Appendix
  6. All Versions of this Article:
    1. dc07-1831v1
    2. 31/3/436 most recent

Current Issue

  1. November 2009, 32 (11)
  1. Current Issue
  1. Alert me to new issues of Diabetes Care