The Rosigliazone Meta-Analysis
Lessons for the future
- Jonathan J. Shuster, PHD1 and
- Desmond A. Schatz, MD2
- 1Department of Epidemiology and Health Policy Research, University of Florida, Gainesville, Florida
- 2Department of Pediatrics, University of Florida, Gainesville, Florida
- Address correspondence and reprint requests to Jonathan J. Shuster, PhD, Department of Epidemiology and Health Policy Research, College of Medicine, University of Florida, P.O. Box 100177, Gainesville, FL 32610-0177. E-mail: jshuster{at}biostat.ufl.edu
We read with interest the recent fixed-effects meta-analysis of the connection between rosiglitazone and both myocardial infarction and cardiac death and the lessons garnered from the Food and Drug Administration Advisory Meeting (1,2). We urge caution in data interpretation. Due to the diversity of the designs (eligibility, doses, duration of follow-up, concomitant medications), we view fixed-effects …
