Tracking and Prediction of Arterial Blood Pressure From Childhood to Young Adulthood in 868 Patients With Type 1 Diabetes

A multicenter longitudinal survey in Germany and Austria

  1. Ina Knerr, MD, PHD1,
  2. Axel Dost, MD, PHD2,
  3. Rudolf Lepler, MD3,
  4. Klemens Raile, MD4,
  5. Edith Schober, MD, PHD5,
  6. Wolfgang Rascher, MD, PHD1,
  7. Reinhard W. Holl, MD, PHD6 and
  8. On behalf of the Diabetes Data Acquisition System for Prospective Surveillance (DPV) Scientific Initiative Germany and Austria
  1. 1Children's and Adolescents’ Hospital, University of Erlangen-Nuremberg, Erlangen, Germany
  2. 2University Children's Hospital, Jena, Germany
  3. 3Children's Hospital Wilhelmstift, Hamburg, Germany
  4. 4University Children's Hospital, Berlin, Germany
  5. 5University Children's Hospital, Vienna, Austria
  6. 6Division of Applied Information Technology, University of Ulm, Ulm, Germany
  1. Address correspondence and reprint requests to Ina Knerr, MD, PhD, Children's and Adolescents’ Hospital, University of Erlangen-Nuremberg, D-91054 Erlangen, Germany. E-mail: ina.knerr{at}uk-erlangen.de

Abstract

OBJECTIVE—Arterial blood pressure was followed in 868 patients with type 1 diabetes aged 6.0–19.9 years in 95 centers in Germany and Austria.

RESEARCH DESIGN AND METHODS—European blood pressure reference data for 28,043 children and adolescents were used with respect to age and sex. Data were stratified into three groups: prepubertal, pubertal, and postpubertal.

RESULTS—Up to 4% of the participants in the younger age-groups and 13.9% of the postpubertal patients exhibited blood pressure values >97th centile. Blood pressure levels correlated with A1C level and BMI Z score. Tracking of blood pressure revealed that children with elevated blood pressure had higher blood pressure in adolescence and young adulthood.

CONCLUSIONS—Patients with higher blood pressure in childhood showed elevated blood pressure later in life. We need to focus on the diagnosis of hypertension in children with type 1 diabetes and to study the efficacy of early intervention.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 9 January 2008. DOI: 10.2337/dc07-1392.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted December 24, 2007.
    • Received July 19, 2007.
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  1. Published online before print January 9, 2008, doi: 10.2337/dc07-1392 Diabetes Care April 2008 vol. 31 no. 4 726-727
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