A Prospective Study of Passive Smoking and Risk of Diabetes in a Cohort of Workers

The High-Risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) study

  1. Yasuaki Hayashino, MD1,
  2. Shunichi Fukuhara, MD1,
  3. Tomonori Okamura, MD2,
  4. Hiroshi Yamato, MD3,
  5. Hideo Tanaka, MD4,
  6. Taichiro Tanaka, MD5,
  7. Takashi Kadowaki, MD2,
  8. Hirotsugu Ueshima, MD2 and
  9. for the HIPOP-OHP Research Group*
  1. 1Kyoto University Graduate School of Medicine, Kyoto, Japan
  2. 2Shiga University of Medical Science, Shiga, Japan
  3. 3University of Occupational and Environmental Health, Fukuoka, Japan
  4. 4Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
  5. 5University of Yamanashi, Yamanashi, Japan
  1. Address correspondence and reprint requests to Yasuaki Hayashino, MD, MPH, Department of Epidemiology and Healthcare Research, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. E-mail: hayasino-y{at}umin.net


OBJECTIVE—We investigated the impact of active smoking and exposure to passive smoke on the risk of developing diabetes.

RESEARCH DESIGN AND METHODS—Data were analyzed from a cohort of participants in the High-Risk and Population Strategy for Occupational Health Promotion Study (HIPOP-OHP) conducted in Japan from 1999 to 2004. Active and passive smoking status in the workplace was evaluated at baseline.

RESULTS—Of 6,498 participants (20.9% women), a total of 229 diabetes cases were reported over a median 3.4 years of follow-up. In the workplace, compared with zero-exposure subjects, the multivariable-adjusted hazard ratios of developing diabetes were 1.81 (95% CI 1.06–3.08, P = 0.028) for present passive subjects and 1.99 (1.29–3.04, P = 0.002) for present active smokers.

CONCLUSIONS—In this cohort, exposure to passive smoke in the workplace was associated with an increased risk of diabetes after adjustment for a large number of possible confounders.


  • Published ahead of print at http://care.diabetesjournals.org on 30 January 2008. DOI: 10.2337/dc07-1905.

  • *

    * A complete list of the members of the HIPOP-OHP Research Group can be found in the appendix.

  • The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted January 19, 2008.
    • Received September 30, 2007.
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