Effect of Lifestyle Intervention on the Occurrence of Metabolic Syndrome and its Components in the Finnish Diabetes Prevention Study

  1. Pirjo Ilanne-Parikka, MD12,
  2. Johan G. Eriksson, MD, PHD34,
  3. Jaana Lindström, PHD3,
  4. Markku Peltonen, PHD3,
  5. Sirkka Aunola, PHD5,
  6. Helena Hämäläinen, MD, PHD6,
  7. Sirkka Keinänen-Kiukaanniemi, MD, PHD789,
  8. Mauri Laakso, MD7810,
  9. Timo T. Valle, MD3,
  10. Jorma Lahtela, MD, PHD11,
  11. Matti Uusitupa, MD, PHD12,
  12. Jaakko Tuomilehto, MD, PHD34 and
  13. on behalf of the Finnish Diabetes Prevention Study Group
  1. 1Diabetes Center, Finnish Diabetes Association, Tampere, Finland
  2. 2Department of Research Administration, Pirkanmaa Hospital District, Tampere, Finland
  3. 3Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
  4. 4Department of Public Health, University of Helsinki, Helsinki, Finland
  5. 5Department of Health and Functional Capacity, Laboratory for Population Research, National Public Health Institute, Turku, Finland
  6. 6Research Department, Social Insurance Institution, Turku, Finland
  7. 7Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland
  8. 8Department of Sport Medicine, Oulu Deaconess Institute, Oulu, Finland
  9. 9Oulu Health Centre, Oulu, Finland
  10. 10Unit of General Practice, Oulu University Hospital, Oulu, Finland
  11. 11Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
  12. 12Department of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
  1. Address correspondence and reprint requests to Pirjo Ilanne-Parikka, Matinkatu 6, FIN 33900 Tampere, Finland. E-mail: pirjo.ilanneparikka{at}diabetes.fi

Abstract

OBJECTIVE—The aim of this secondary analysis of the Finnish Diabetes Prevention Study was to assess the effects of lifestyle intervention on metabolic syndrome and its components.

RESEARCH DESIGN AND METHODS—A total of 522 middle-aged overweight men and women with impaired glucose tolerance were randomized into an individualized lifestyle intervention group or a standard care control group. National Cholesterol Education Program criteria were used for the definition of metabolic syndrome.

RESULTS—At the end of the study, with a mean follow-up of 3.9 years, we found a significant reduction in the prevalence of metabolic syndrome in the intervention group compared with the control group (odds ratio [OR] 0.62 [95% CI 0.40–0.95]) and in the prevalence of abdominal obesity (0.48 [0.28–0.81]).

CONCLUSIONS—The results suggest that lifestyle intervention may also reduce risk of cardiovascular disease in the long run.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 9 January 2008. DOI: 10.2337/dc07-1117. Clinical trial reg. no. NCT00518167, clinicaltrials.gov.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    • Accepted December 24, 2007.
    • Received August 15, 2007.
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  1. Published online before print January 9, 2008, doi: 10.2337/dc07-1117 Diabetes Care April 2008 vol. 31 no. 4 805-807
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