Insulin Resistance Is Associated With Decreased Circulating Mannan-Binding Lectin Concentrations in Women With Polycystic Ovary Syndrome
- Irina Kowalska, MD1,
- Jose Manuel Fernandez-Real, MD2,
- Marek Straczkowski, MD1,
- Agnieszka Kozlowska, MD1,
- Agnieszka Adamska, MD1,
- Francisco Ortega, MD2,
- Agnieszka Nikolajuk, PHD1,
- Monika Karczewska-Kupczewska, MD1,
- Slawomir Wolczynski, MD3 and
- Maria Gorska, MD1
- 1Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
- 2Section of Diabetes, Endocrinology and Nutrition, University Hospital of Girona, Girona, Spain and CIBER Fisiopatologia de la Obesidad y Nutricion CB/06/03/010, Girona, Spain
- 3Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Bialystok, Poland
- Address correspondence to Irina Kowalska, MD, Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M.C. Sklodowskiej 24a, 15-276 Bialystok, Poland. E-mail: irinak{at}poczta.onet.pl
Insulin resistance has been described as associated with low levels of mannan-binding lectin (MBL), a protein of the innate immune system (1). The aim of the present study was to study serum MBL concentration in polycystic ovary syndrome (PCOS) in relation to insulin resistance, adiponectin, and high-sensitivity C-reactive protein (hsCRP). Insulin sensitivity, serum MBL concentration, adiponectin, hsCRP, and sex hormones were measured in 102 PCOS (34 of whom were lean and 68 overweight or obese) …
