Insulin Resistance and Progression to Type 1 Diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT)
Response to Bingley et al.
- From the Department of Endocrinology & Metabolism, Peninsula Medical School (Plymouth Campus), Plymouth, U.K.
- Address correspondence to Terence J. Wilkin, Professor of Endocrinology & Metabolism, Peninsula Medical School (Plymouth Campus), University Medicine, Level 7, Derriford Hospital, Plymouth PL6 8DH, Plymouth, U.K. E-mail: terence.wilkin{at}phnt.swest.nhs.ulc
The accelerator hypothesis proposes that type 1 and type 2 diabetes are both driven by insulin resistance (1), and its principle prediction is an inverse correlation between BMI and age at onset in children with type 1 diabetes. Bingley et al. (2) examined ENDIT data and found evidence for an inverse correlation only among those with advanced β-cell loss (low first-phase insulin response) (FPIR). They conclude that insulin …
