Serum Prostate-Specific Antigen Levels in Men With Type 2 Diabetes

  1. Michiaki Fukui, MD1,
  2. Muhei Tanaka, MD1,
  3. Mayuko Kadono, MD1,
  4. Saeko Imai, PHD2,
  5. Goji Hasegawa, MD1,
  6. Toshikazu Yoshikawa, MD1 and
  7. Naoto Nakamura, MD1
  1. 1Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
  2. 2Department of Clinical Nutrition, Faculty of Comprehensive Rehabilitation, Osaka Prefecture University, Osaka, Japan
  1. Corresponding author: Michiaki Fukui, MD, Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. E-mail: sayarinapm{at}hotmail.com

Abstract

OBJECTIVE—The aims of this study were to examine if serum prostate-specific antigen (PSA) levels are lower in men with type 2 diabetes compared with those in healthy men and to investigate what factors may be associated with serum PSA levels in men with type 2 diabetes.

RESEARCH DESIGN AND METHODS—We compared the serum PSA levels in 224 diabetic men with those in 1,293 healthy men and investigated the relationships between serum PSA levels and various variables.

RESULTS—Except for men aged 40–49 years, serum PSA levels were lower in diabetic men than in healthy men. Multiple regression analysis demonstrated that age, BMI, and presence of diabetes were independent determinants of serum PSA level.

CONCLUSIONS—Serum PSA levels were lower in diabetic men compared with those in healthy men, which is in line with previous reports that patients with type 2 diabetes are at a decreased risk of prostate cancer.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 14 February 2008. DOI: 10.2337/dc07-1962.

    Additional information for this article can be found in an online appendix at http://dx.doi.org/10.2337/dc07-1962.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted January 25, 2008.
    • Received October 10, 2007.
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  1. Published online before print February 14, 2008, doi: 10.2337/dc07-1962 Diabetes Care May 2008 vol. 31 no. 5 930-931
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